Since 2020, aggregated from related topics
L-DOPA-induced dyskinesia is a side effect associated with the long-term use of levodopa (L-DOPA) in the treatment of Parkinson's disease. Dyskinesias are abnormal involuntary movements that can be choreic, dystonic, or athetoid in nature, and they tend to occur as a response to the fluctuations in dopamine levels caused by L-DOPA therapy. The exact mechanisms underlying L-DOPA-induced dyskinesia are not fully understood, but it is believed to involve changes in the dopamine receptor signaling, alterations in the basal ganglia circuitry, and abnormal plasticity in the brain. Management of L-DOPA-induced dyskinesia typically involves adjusting the medication dosages, adding adjunct therapies, or considering surgical interventions such as deep brain stimulation.